Rejuvenating Bi(d)ology
نویسندگان
چکیده
منابع مشابه
Rejuvenating regeneration
the transcriptional coactivator CREB-binding protein, also known as CREBBP or CBP, maximizes embryonic neural precursor cell development. 5 These researchers also demonstrated that the effects of CBP on neurogenesis require CBP activation by atypical protein kinase C (aPKC). Because Wondisford and colleagues had demonstrated that metformin's ability to suppress hepatic gluconeogenesis requires ...
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Tennyson tells us of Tithonus, who was endowed with immortality and was never permitted to perish, despite his wishes to that end. A biological parallel might be pluripotent stem cells, which can be indefinitely propagated in vitro in an uncommitted, self-renewing state, and can form all lineages in the mammalian body [1]. However, pluripotency is an inherently transient condition in vivo. Thus...
متن کاملRejuvenating clinician-scientist training.
Clinician-scientists are becoming increasingly rare in medicine as a whole, but especially in ophthalmology. There is a structural gap between MD-PhD training and K-series awards where interested candidates go through residency and fellowship without any structured research exposure or involvement. Furthermore, the success rate of the MD-PhD and K awards leaves much to be desired. The authors p...
متن کاملRejuvenating C++ programs through demacrofication
We describe how legacy C++ programs can be rejuvenated using C++11 features such as generalized constant expressions, perfect forwarding, and lambda expressions. In general, this work develops a correspondence between different kinds of macros and the C++ declarations to which they should be transformed. We have created a set of demacrofication tools to assist a developer in the rejuvenation of...
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mammalian neurons, C. elegans neurons lose regeneration ability as they age, but it is not known why. C. elegans is a soil worm with its brain wiring diagram being mapped entirely-every connection between every nerve cell. Forty percent of genes identified in the worm genome have a counterpart in humans. Genes that allow neurons to connect with each other to form functional neuronal circuits an...
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ژورنال
عنوان ژورنال: Oncogene
سال: 2012
ISSN: 0950-9232,1476-5594
DOI: 10.1038/onc.2012.454